However, we will have to solve the problem of comparing the expression profiles of macro-molecules between torpid and flying bats because bats are no longer flying when they are captured. We plan to investigate metabolic activities in different bat tissues in different physiological states. More multi-disciplinary approaches are needed to learn this incredible metabolic regulation of hibernating bats. Friends who work together: Tianxiao Yang (left) and Tengteng Zhu (right) Using multi-disciplinary approaches, we revealed complex strategies used by Myotis ricketti bats for metabolic adjustment against cold, including co-activation of Nrf2, Akt, and NF-κB via the PERK-EIF2-ATF4 signaling pathway and anti-apoptotic responses. We also used cold-stimulated and fasted mice as a model of induced torpor, which is an idea inspired by previous investigations of physiological differences between induced and natural torpor of small mammals. To learn metabolic regulations of hibernating bats at the molecular level, we separately collected these samples from torpid, arousal, and summer active bats and compared protein expression profiles of these three bat groups. Liver cells and their mitochondria are energy suppliers of mammals. Bat Research and Conservation Station, Fangshan, China. This makes them an ideal model to learn metabolic regulations of microbats. We found theses bats torpor deeply in the cave from late October to middle April next year. We performed a long-term tracking of Myotis ricketti bats (Rickett’s big-footed bat, family Vespertilionidae) that habit in Fangshan cave (39 ☄8′N, 115 ☄2′E), Beijing, China from 2004 to 2010. How do these bats survive this repeated and dramatic change of metabolism? They can reduce their metabolic rate to an amazingly low level (< 5%) during torpor and recover the rate promptly upon arousal. Most bats that enter deep torpor during winter hibernation are microbats.
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